- breathing problems such as shortness of breath and chest tightness
- nausea
- diarrhea
- fatigue
- increase in a certain blood enzyme called creatine phosphokinase
- rash
Vertex offers several cystic fibrosis (CF) treatment options for patients of certain ages with specific CF gene mutations. Not everyone with CF is eligible for a Vertex treatment option. Select an age range and CF gene mutation to see if one of our approved medicines may be an option for you or your loved one.
SYMDEKO is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 12 years and older who have two copies of the F508del mutation, or who have at least one mutation in the CF gene that is responsive to treatment with SYMDEKO.
Talk to your doctor to learn if you have an indicated CF gene mutation.
It is not known if SYMDEKO is safe and effective in children under 12 years of age.
Talk to your doctor before taking SYMDEKO if you take any of the medicines or herbal supplements listed above.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of SYMDEKO may need to be adjusted when taken with certain medicines.
Especially tell your doctor if you take:
SYMDEKO can cause serious side effects, including:
Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.
Call your doctor right away if you have any of the following symptoms of liver problems:The most common side effects of SYMDEKO include headache, nausea, sinus congestion, and dizziness.
These are not all the possible side effects of SYMDEKO. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
Click here for SYMDEKO full Prescribing Information, including Patient Information.
ORKAMBI is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients age 2 years and older who have two copies of the F508del mutation (F508del/F508del) in their CFTR gene.
ORKAMBI should not be used in patients other than those who have two copies of the F508del mutation in their CFTR gene.
It is not known if ORKAMBI is safe and effective in children under 2 years of age.
Talk to your doctor before taking ORKAMBI if you take any of the medicines or supplements listed above.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of ORKAMBI may need to be adjusted when taken with certain medicines.
Especially tell your doctor if you take:
Tell your doctor if you stop ORKAMBI for more than 1 week. Your doctor may need to change your dose of ORKAMBI or other medicines you take.
ORKAMBI can cause serious side effects, including:
The most common side effects of ORKAMBI include:
Side effects seen in children are similar to those seen in adults and adolescents. Additional common side effects seen in children include:
These are not all the possible side effects of ORKAMBI. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
Click here for ORKAMBI full Prescribing Information, including Patient Information.
KALYDECO is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients age 12 months and older who have at least one mutation in their CF gene that is responsive to KALYDECO.
Talk to your doctor to learn if you have an indicated CF gene mutation.
It is not known if KALYDECO is safe and effective in children under 12 months of age.
Do not take KALYDECO if you take certain medicines or herbal supplements, such as:
Talk to your doctor before taking KALYDECO if you take any of the medicines or supplements listed above.
Before you take KALYDECO, tell your doctor if you:
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements, as the dose of KALYDECO may need to be adjusted when taken with certain medications.
Especially tell your doctor if you take:
KALYDECO can cause serious side effects.
High liver enzymes in the blood have been reported in patients receiving KALYDECO. Your doctor will do blood tests to check your liver:
For patients who have had high liver enzymes in the past, the doctor may do blood tests to check the liver more often.
Call your doctor right away if you have any of the following symptoms of liver problems:
Abnormality of the eye lens (cataract) has been noted in some children and adolescents receiving KALYDECO. Your doctor should perform eye examinations prior to and during treatment with KALYDECO to look for cataracts.
The most common side effects include:
Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of KALYDECO. For more information, ask your doctor or pharmacist.
Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
Click here for KALYDECO full Prescribing Information, including Patient Information.
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